Neue Strategien zur Modifikation von immobilisierten Building Blocks durch on-bead-Derivatisierung und funktionalisierende Abspaltung vom Trager

By (author) Nicolai A Wippert

Book cover: Neue Strategien zur Modifikation von immobilisierten Building Blocks durch on-bead-Derivatisierung und funktionalisierende Abspaltung vom Trager

Extent: 219, 219 pages

Publisher: Logos Verlag Berlin

Subjects: Earth & Life Sciences 

Series: Beiträge zur organischen Synthese

Series volume number: 87

Language: German

Paperback (Published)

(April 2020)

ISBN: 9783832551025

5.71 x 8.27 inches

Price: $65.00

Out of stock

Die Festphasensynthese stellt eine effektive Methode zur Darstellung von Substanzbibliotheken dar. So bietet sie zum Beispiel die Moglichkeit, durch den Austausch an Reaktanden, das Zielmolekul an einer spezifischen Stelle abzuandern, um so ein Derivat des ursprunglichen Molekuls zu erhalten. Wenn auch die industrielle Anwendung im Laufe der letzten beiden Jahrzehnte zuruckgegangen ist, so findet sie in gewissen Bereichen, wie der Peptid-Synthese weiterhin grossen Zuspruch. Im Rahmen dieser Arbeit wurden neue Methoden etabliert, um eine neue Syntheseroute zur Darstellung von Pyr-3-Analoga zu finden. Mit Hilfe dieser Methoden konnte eine kleine bis mittelgrosse Substanzbibliothek solcher Derivate hergestellt werden. Des Weiteren wurde ein neuer Festphasen-Triazen-Linker hergestellt, bei dem erstmals ein Pyrazol-Heterocyclus uber das Triazen-Motiv an die Feste Phase angebunden und derivatisiert werden konnte. Dieser Linker bietet einen neuen Ansatz, um verschiedene Bibliotheken dieser Substanzklasse herzustellen, welche dann auf ihre biologische Aktivitat uberpruft werden konnen. Zuletzt konnten einige der gefundenen Methoden auf die klassische “Flussigphasen-Chemie” ubertragen werden und somit deren Relevanz verstarkt werden.

  • By (author) Nicolai A Wippert

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