Design, Synthesis and Evaluation of Highly Functionalized Peptoids as Antitumor Peptidomimetics

By (author) Carmen Cardenal

Extent: 170 pages

Publisher: Logos Verlag Berlin

Subjects: Earth & Life Sciences

Series: Beiträge zur organischen Synthese

Series volume number: 47

Language: English

Paperback (Published)

(June 2014)

ISBN: 9783832537210

5.75 x 8.31 inches

Price: $63.00

On back order

Add to cart -
back order

Synopsis
Contributing Authors

Peptides perform a wide variety of essential functions in living organisms with great specificity and precision. However, their therapeutic use is limited, due to their fast degradation by proteases in vivo and consequent poor oral bioavailability. Thanks to their proteolytic resistance and easily accessible and derivatizable synthesis on solid supports, peptoids (N-substituted glycine oligomers) have emerged as promising peptidomimetics for biological and medical applications. In this work peptoid analogs of two short amino acid sequences with antitumor activity (one derived from the CD44-v6 coreceptor and one from the BAG-1L protein), have been designed and synthesized. Comparison of the biological activity of the peptides and the different peptoid analogs led to the establishment of structure-activity relationships and the identification of a lead compound showing high potential for cancer therapy. In addition, a method for the synthesis of amide-containing submonomers as free bases and their incorporation into peptoid oligomers is described. Different-length homo-oligomers of alpha-chiral amide residues were successfully synthesized for structural investigations.

By (author) Carmen Cardenal

Other Titles in this Series

Design and Synthesis of Emissive and Switchable Photo-Active Molecules

Volume 98

By (author) Gloria Hong

Synthesis of Cannabinoid Ligands

Novel Compound Classes, Routes and Perspectives

Volume 73

By (author) Thomas Hurrle

Synthetic cannabinoids in drug discovery

Design, synthesis and evaluation of modified coumarins as CB receptor ligands

Volume 88

By (author) Florian Mohr

Synthesis and design of unsymmetrical quinoxaline-based oligomer with tunable backbone

Volume 99

By (author) Jerome Klein

Novel Lanthanide-Based Luminescent Probes for Biological and Lighting Applications

Volume 76

By (author) Alena Kalyakina

Synthesen trans-A2B2-substituierter Porphyrinlinker zur Darstellung photoaktiver oberflachenverankerter MOF-Dunnschichten

Volume 90

By (author) Stefan Marschner

Novel Organic Emitters for Thermally Activated Delayed Fluorescence

Volume 100

By (author) Celine Leonhardt

Structure Performance Relationships of the Novel MALDI-MS Matrices

Volume 72

By (author) Suparna Tambe

Sulfonyl Ynamides as Useful Tools for N-Heterocyclic Chemistry

Volume 62

By (author) Tim Wezeman

MOF Linkers Based on Porphyrin and Phthalocyanine Structures

Volume 101

By (author) Lukas Langer

Metal-Catalyzed N-H and O-H Insertion from alpha-Diazocarbonyl Compounds

Volume 79

By (author) Yuling Hu

New Emitters for OLEDs

The Coordination- and Photo-Chemistry of Mononuclear Neutral Copper(I) Complexes

Volume 57

By (author) Larissa Bergmann

Organic Semiconductors based on [2.2]Paracyclophanes and Porphyrins as Hole Transport Materials in Perovskite Solar Cells

Volume 102

By (author) Steffen Andreas Otterbach

Zyklische Hybride – Rigide Modellstrukturen fur neue Theranostika

Volume 94

By (author) Claudine Herlan

Synthesis and Characterization of Luminescent Cu(I) Complexes

Volume 58

By (author) Manuela Wallesch

Novel NHC-iridium complexes for advanced application of hyperpolarized NMR

Volume 103

By (author) Simon Osswald

Methods for adapting virtual environments to the challenges of efficient digitization strategies in synthetic chemistry

Volume 83

By (author) Yu-Chieh Huang

Synthesis and Biomedical Applications of Multifunctional Poly(ethylene glycol) Derivatives

Volume 38

By (author) Ekaterina Sokolovskaya

Development of New Synthetic Approaches towards the Anthraquinone-Xanthone Heterodimeric Structure of Beticolin 0

Volume 91

By (author) Janina Beck

Computer-Aided Information Retrieval and Management System from Scientific Documents

Volume 86

By (author) Thanh Cam An Nguyen

Virantmycin und Spiculoinsaure A – die intramolekulare Diels-Alder-Reaktionin in der Synthese komplexer Naturstoffe

Volume 4

By (author) Daniel Keck

Design and Synthesis of N-Heterocyclic Donor Based TADF Emitters for Application in OLEDs

Volume 92

By (author) Zhen Zhang

Modular Design Strategies for TADF Emitters

Towards Highly Efficient Materials for OLED Application

Volume 84

By (author) Fabian Hundemer

Synthesis of Azide-containing Molecules and C3-symmetric Building Blocks

Volume 104

By (author) Lisa Schmidt

Synthese von Kupfer(I)- und Silber(I)-Komplexen zur Untersuchung kooperativer Effekte und Anwendung in OLEDs

Volume 93

By (author) Jasmin Busch

Book cover: Neue Strategien zur Modifikation von immobilisierten Building Blocks durch on-bead-Derivatisierung und funktionalisierende Abspaltung vom Trager

Neue Strategien zur Modifikation von immobilisierten Building Blocks durch on-bead-Derivatisierung und funktionalisierende Abspaltung vom Trager

Volume 87

By (author) Nicolai A Wippert

Synthesis of Functional Quinoxaline Derivatives for the Application in Biology and Materials Sciences

Volume 105

By (author) Laura Holzhauer

Development of Rigid Aromatic Building Blocks for the Application in Material Sciences

Volume 95

By (author) Yannick Matt

Heterobimetallic [2.2]Paracyclophane Complexes and Their Application in Photoredox Catalysis

Volume 85

By (author) Daniel Knoll

Development of Novel Routes and Methods for the Semisynthesis of the Marine Steroid Demethylgorgosterol and Unnatural Analogs

Volume 97

By (author) Nicolai Rosenbaum

Similar Books

Alfonsine Astronomy

Computational Practices

Volume 3

Edited by Mathieu Husson Edited by Jose Chabas Edited by Richard Kremer Edited by Matthieu…

Anode-Free Rechargeable Batteries

Design, Performance, and Upscaling

Edited by Hua Wang

Artificial Intelligence in Chemistry and Chemical Engineering

From Basics to Practical Exercises

Edited by Kuangbiao Liao

Chalcogenide Nanophotonics

By (author) Tun Cao By (author) Ying Su By (author) Yinghan Li By (author) Hongze…

Computational modeling of the FeTi hydrogenation

Scale-bridging atoms and microstructure

By (author) Ebert Daniel Macedo Alvares

Conjugated Polymer Synthesis and Materials Applications

Edited by Yoshiki Chujo

Core-Shell Nanomaterials

From Fundamentals to Applications

By (author) Shreya Sharma By (author) Peeyush Phogat By (author) Jahanvi Thakur By (author) N.…

Defect Engineering in Photocatalysis

From Fundamentals to Applications

Edited by Chuanyi Wang Edited by Abdelkader Labidi Edited by Qiuhui Zhu

Density-Based Reactivity Theory

By (author) Shubin Liu

Diagnostic Techniques in Public Health

Analytical and Chemometric Approaches in Disease Detection and Management

Edited by Jinghong Li Edited by Yan Du

Distributed model predictive control for dynamic multi-agent cooperation

By (author) Matthias Köhler

Drug Development Approaches for Poorly Soluble Compounds

Edited by Yogeshwar Bachhav Series edited by Helmut Buschmann Series edited by Jörg Holenz Series…

Drug Discovery Targeting Metalloenzymes

Strategies and Applications

Edited by Guo-Bo Li

Ecological Conversion and the Murray River

Towards a Changed Relation with a Great River System

By (author) Emmanuel D. Bautista

Electrochemical Strategies in Organic Synthesis

By (author) Goutam Brahmachari

Engineering Illumination Optics

Case Studies and Exercises

By (author) Henning Rehn By (author) Julius Muschaweck

Essentials of Carbohydrate Chemistry and Biochemistry

By (author) Thisbe K. Lindhorst

Excited State Dynamics in DNA and RNA

Experimental and Computational Approaches on Triplet State

Edited by Jinquan Chen

Field-Flow Fractionation

Principles and Applications

Edited by Céline Guéguen Edited by Mohammed Baalousha Edited by S. Kim R. Williams

Fluorescent Probes for Bioactive Species

Design, Synthesis, and Biomedical Applications

Edited by Caixia Yin

Food and the Elements

Proceedings of the Oxford Symposium on Food and Cookery 2025

Edited by Mark McWilliams

Fundamentals of Electrochemistry

Principles, Methods, Materials, Applications

By (author) Gunther Wittstock Translated by Gunther Wittstock Translated by Frank Marken Translated by

Global Legal Pluralism and Rights of Nature

Volume 151

Edited by Daniel Bonilla Maldonado Edited by Ralf Michaels

Gravity

Life's Ups and Downs

By (author) David Howe

Hybrid Water Electrolysis

Non-Oxide Electrocatalysts in Small Molecule Oxidation

Edited by Myong Yong Choi Edited by Jayaraman Theerthagiri Edited by M. L. Aruna Kumari…

Innovation Management in Sustainable Chemistry

By (author) Gadi Rothenberg

Interactions of Light with Small Particles

By (author) Craig F. Bohren By (author) Donald R. Huffman By (author) Eugene E. Clothiaux

Iron-Group Metal Compound Nanomaterials

Preparation, Characterization, Structure, and Applications

By (author) Jinlong Zheng

Late-Stage Functionalization and Diversification in Organic Synthesis

Methods and Applications

Edited by Tatiana Besset Preface by Tobias Ritter

Lens Design for Imaging

Volume 2: Aberration Theory

By (author) Herbert Gross

Medicinal Chemistry of Plant-Derived Natural Products

A Chemical Exploration of Plants as a Source of Modern Drugs

By (author) Enrique Ravina

Metal Nanocluster Catalysis

From Fundamentals to Applications

By (author) Manzhou Zhu By (author) Man-Bo Li

Metal Oxide Nanocatalysts for Sustainable Energy Production

Edited by Abayomi Bamisaye Edited by Sesan Abiodun Aransiola Edited by Nelson Oshogwue Etafo Edited…

Molecular Design of Opto-Electronic Materials

From Single Molecules to Molecular Aggregates

Edited by Zhen Li

Molecule and Ion Transport through Polymer Membranes

By (author) Yong Soo Kang

Naming Pathology from Antiquity to the Early Modern Period

Volume 20

edited by Alessandra Foscati and Michele Goyens

Our Multispecies Futures

Control, Care and Kinship in a Transformed World

By (author) Vetri Nathan

Photocatalysts based on Carbon Scaffolds

Environmental and Industrial Applications

Edited by Ramesh Oraon Edited by Pardeep Singh Edited by Mika Sillanpaa Edited by Ganesh…

Photofunctional Polymer Composites for Bioapplications

By (author) Xiaoyu Wang By (author) Lidong Li

Physics of Nerves and Excitatory Membranes

By (author) Thomas Heimburg

Polarization-Based Optical Imaging for Clinical Diagnostics

Edited by Yurii Ushenko Edited by Weidong Dou Edited by Oleksandr Ushenko Edited by Oleksandr…

Quantum Mechanics

Volume II: Angular Momentum, Spin, and Approximation Methods

By (author) Claude Cohen-Tannoudji By (author) Franck Laloe Translated by Nicole Ostrowsky Translated by Daniel…

Design, Synthesis and Evaluation of Highly Functionalized Peptoids as Antitumor Peptidomimetics

Tell a Colleague/Librarian/Friend

Other Titles in this Series

Similar Books

Join the ISD Mailing List