Methodenentwicklung an der festen Phase

Kombinatorische Abspaltung immobilisierter pseudo-Oxazolone als biologisch relevante Leitstrukturen

By (author) Patrick Hodapp

Image coming soon

Extent: 207, 207 pages

Publisher: Logos Verlag Berlin

Subjects: Earth & Life Sciences 

Series: Beiträge zur organischen Synthese

Series volume number: 81

Language: German

Paperback (Published)

(August 2019)

ISBN: 9783832549541

5.71 x 8.27 inches

Price: $58.00

Out of stock

Die Festphasensynthese bietet die Moglichkeit, kosten-, zeit- und ressourceneffizient kleine Molekulbibliotheken mit vielfaltiger Derivatisierung in kombinatorischer Art fur die Wirkstoff- und biochemische Forschung zu synthetisieren. Jedoch ist die dafur notwendige Vorarbeit zur Methodenentwicklung geeigneter Protokolle fur die Festphasensynthese sehr aufwandig und wird deswegen industriell als kombinatorische Synthesemoglichkeit fur kleine organische Molekule nur noch wenig betrieben. In der hier vorgestellten Arbeit wurden Festphasenprotokolle zur Darstellung verschiedener biochemisch interessanter Leitstrukturen mit heterocyclischem Grundgerust erarbeitet. Ausgehend von immobilisierten pseudo-Oxazolonen konnten verschieden substituierte Chinoxalinone, Benzoxazinone und Benzothiazole, uber eine cyclisierende Abspaltung der immobilisierten pseudo-Oxazolone durch bifunktionale Nukleophile dargestellt werden. Ferner wurde durch Abspaltungen mit Dithianylium-Salzen eine neue Strukturklasse mit einem Dithia-spirononenon Grundgerust erschlossen.

  • By (author) Patrick Hodapp

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