Synthesis of derivatized indoles by photocatalyzed reactions in batch- and microreactors
By (author) Helena Simek Tosino
Paperback (Published)
(June 2024)
ISBN: 9783832558031
5.71 x 8.27 inches
Price: $89.00
Out of stock
This work investigated a novel photochemical cyclization to form indole derivatives from o-alkynylated F-tagged aniline derivatives, and wide applicability to synthesize differently functionalized indole systems bearing various substituents in the positions N-1, C-2, C-3, C-5 and C-6 was shown. Additionally, this reaction was systematically studied in a kinetic study in an in-house assembled capillary photo-microreactor. Further derivatization of the final F-tagged 3-acylindoles by the cleavage of the perfluorinated chain yielded a library of novel indole-3-carboxylic acid and indole-3-carboxylic acid ester derivatives. A straightforward and efficient four-step methodology for the synthesis of desired indole derivatives with high yields for single steps and the whole sequence was developed. Variing the conditions of single steps showed that all three steps of the reaction route to the cyclization precursors can be performed using the same solvent and base, providing the possibility to conduct this sequence as a continuous-flow without the need for in-line solvent switch or base exchange and without compromises with respect to the selectivity and yields of single steps.
- By (author) Helena Simek Tosino
Other Titles in this Series
Design, Synthesis and Evaluation of Highly Functionalized Peptoids as Antitumor Peptidomimetics
Volume 47
Modular Design Strategies for TADF Emitters
Towards Highly Efficient Materials for OLED Application
Volume 84
![Book cover: Heterobimetallic [2.2]Paracyclophane Complexes and Their Application in Photoredox Catalysis](https://isd.stisonbooks.com/images/books/native/9783832550714.jpg?asset_id=46694)
Heterobimetallic [2.2]Paracyclophane Complexes and Their Application in Photoredox Catalysis
Volume 85
![Book cover: Synthesis and Application of [2.2]Paracyclophane Derivatives in Catalysis and Material Science](https://isd.stisonbooks.com/images/books/native/9783832554125.jpg?asset_id=72802)
Synthesis and Application of [2.2]Paracyclophane Derivatives in Catalysis and Material Science
Volume 96
![Book cover: Synthesis and modification of bicyclo[1.1.1]pentyl sulfides](https://isd.stisonbooks.com/images/books/native/9783832551094.jpg?asset_id=57030)
Synthetic cannabinoids in drug discovery
Design, synthesis and evaluation of modified coumarins as CB receptor ligands
Volume 88
New Emitters for OLEDs
The Coordination- and Photo-Chemistry of Mononuclear Neutral Copper(I) Complexes
Volume 57
![Book cover: Organic Semiconductors based on [2.2]Paracyclophanes and Porphyrins as Hole Transport Materials in Perovskite Solar Cells](https://isd.stisonbooks.com/images/books/native/9783832557096.jpg?asset_id=75237)
Similar Books
Reframing Restoration
Rwanda Re-photographed 100 Years Later or the Reconstruction of Landscape Memory
The Archaeology of Irrigation Technology and Water Management in the Islamic World
Proceedings of the Bahrain Conference, January 2024
Die “Schweizer Ärztinnen” der Habsburgermonarchie
Weibliche Karrieren, Handlungsspielräume und Grenzüberschreitungen im späten 19. und frühen 20. Jahrhundert
Ernst Haeckel: Ausgewählte Briefwechsel. Historisch-kritische Ausgabe. Bd. 22
Korrespondenz zu Weltanschauung, Kunst und Literatur. Österreich und Schweiz August 1894 – August 1914
Forschen und Übersetzen
Translation im (früh)modernen Wissenschaftssystem am Beispiel Frankreichs (1600–1815)
Kontroverse Sicherheit
Atomwirtschaft und Kernenergiediskussion in der Bundesrepublik Deutschland (1975–1992)
Nouvelles normes, surtout pas de panique! / Neue Normen, nur keine Panik!
Reguler les pollutions en Suisse a l'age industriel / Umweltverschmutzung und Regulierung in der industrialisierten Schweiz
Socialitas, urbanitas, humanitas
Die Leipziger Sozietäten im 17. Jahrhundert zwischen Späthumanismus, lutherischer Orthodoxie und Frühaufklärung