Pyrrolizidine Alkaloids
Structure and Toxicity
By (author) Helmut Wiedenfeld By (author) Erhard Roeder By (author) Thomas Bourauel By (author) John Edgar
Hardback (Out of print)
(January 2008)
ISBN: 9783899714265
6.34 x 9.69 inches
Price: $82.00
On back order
Pyrrolizidine alkaloids show only minor toxicity in their native state, but are metabolized in the human or animal organisms to carcinogenic, teratogenic and mutagenic compounds, with the precise structure of these compounds being responsible for the metabolic toxification process. Therefore, to be able to evaluate the toxic potential of each alkaloid, it is essential to exactly know the structure of the respective compound. X-ray structure analysis is the appropriate method both for elucidating the structure and for determining other parameters, such as the lengths of the bonds that influence the metabolic process. This book describes the incidence and the process of the intoxication as well as the possibilities to how the substances may reach the organism. In addition, the compounds elucidated by X-ray structure analysis to date are shown in their three-dimensional structure and structure-toxicity relationships are discussed.Pyrrolizidinalkaloide weisen in nativem Zustand nur geringe Toxizität auf, werden jedoch zu kanzerogenen, teratogenen und mutagenen Verbindungen metabolisiert, wenn sie in den menschlichen oder tierischen Organismus gelangen. Der Verlauf dieser Toxifizierung hängt von der konkreten Struktur dieser Stoffe und weiteren Parametern ab. Zur Bestimmung dieser Faktoren stellt die Röntgenstrukturanalyse die geeignete Methode dar. Im vorliegenden Buch werden das Vorkommen, der Ablauf der Toxifizierung und die Möglichkeiten, wie die Stoffe in den Organismus gelangen können, beschrieben. Es werden die bislang durch Röntgenstrukturanalyse vermessenen Verbindungen in ihrer 3D-Struktur aufgeführt und Struktur-Toxizitätsbeziehungen diskutiert.
Dr. Helmut Wiedenfeld ist Akademischer Direktor am Pharmazeutischen Institut der Universität Bonn.
- By (author) Helmut Wiedenfeld
- By (author) Erhard Roeder
- By (author) Thomas Bourauel
- By (author) John Edgar
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