Mechanisms conferring robustness to Erk1/2 signalling

By (author) Franziska Witzel

Book cover: Mechanisms conferring robustness to Erk1/2 signalling

Extent: 172 pages

Publisher: Logos Verlag Berlin

Subjects: Earth & Life Sciences 

Language: English

Paperback (Published)

(November 2015)

ISBN: 9783832541132

5.71 x 8.27 inches

Price: $65.00

Out of stock

^TMechanisms Conferring Robustness to Erk1/2 Signalling ^Aby Franziska Witzel ^DOn the molecular scale even clonal cells do not look alike, as gene expression is inherently stochastic and in consequence protein levels fluctuate. Cellular signal transduction pathways are affected by this gene expression noise, as proteins relay information about the environment to the nucleus, ultimately regulating cell fate decisions. So how can signalling work in a reliable and reproducible fashion? A combination of experiments and mathematical modelling reveals how negative feedbacks and phosphorylation cycles create the remarkable robustness of MAPK signalling when the concentration of Erk1/2 is increased or reduced by targeted perturbations.

  • By (author) Franziska Witzel