Zum biologischen Verhalten des malignen Melanoms der Haut in der umgebenden Matrix

by Uwe-Frithjof Haustein, Ulf Anderegg and Anja Saalbach

Book cover: Zum biologischen Verhalten des malignen Melanoms der Haut in der umgebenden Matrix

Extent: 29 pages

Publisher: S. Hirzel Verlag

Subjects: Medicine

Series: Sitzungsberichte der Sachsischen Akademie der Wissenschaften zu Leipzig. Mathematisch - naturwissenschaftliche Klasse

Series volume number: 129.2

Language: German

Paperback (Published)

(January 2004)

ISBN: 9783777612850

Price: $14.00

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Am malignen Melanom erkranken in Deutschland jahrlich 10000 Menschen, 20-25% versterben an diesem Hauttumor. Die Haufigkeit des Auftretens hat sich in den letzten 15 Jahren verdoppelt. Im Fruhstadium mit relativ geringer Tumordicke ist das MM mit 97% gut heilbar. Die Ultraviolett-Exposition, insbesondere Sonnenbrande im Kindesalter fuhren zu direkten DNA-Schaden und zur Bildung reaktiver Sauerstoffspezies, wodurch die Tumorentwicklung begunstigt wird. Genetik, klinisches Bild, histopathologische und dermatoskopische Untersuchungsmethoden sowie die Pathogenese des MM werden kurz besprochen. Die Prognose des MM hangt in erster Linie von der Tumordicke ab. Bei der Tumorentstehung werden folgende biologische Phasen durchlaufen:1. Verlust der genetischen Stabilitat der Melanozyten2. Loslosung aus ihrer dermalen Funktionseinheit3. Verlust der Wachstumskontrolle4. Fahigkeit zum invasiven Wachstum und Metastasierung

  • By (author) Ulf Anderegg
  • By (author) Uwe-Frithjof Haustein
  • By (author) Anja Saalbach

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