Successful Drug Discovery
Volume 4
Edited by János Fischer Edited by Christian Klein Edited by Wayne E. Childers
Hardback (Out of print)
(September 2019)
ISBN: 9783527344680
6.69 x 9.65 inches
Price: $194.00
On back order
Provides unique insider insight into the current drug development process, and what it takes to achieve success
In this fourth volume in the series, inventors and primary developers of drugs that made it to the market continue telling the story of the drugs? discovery and development, and discuss the sometimes twisted route from the first drug candidate molecule to the final marketed one. Beginning with a general section addressing overarching topics for drug discovery, the book offers seven chapters that feature selected case studies describing recently introduced drugs or drug classes. These include small molecule drugs as well as biopharmaceuticals and range across different therapeutic fields. Together, they provide a representative cross-section of the present-day drug development effort.
Successful Drug Discovery: Volume 4 covers trends in peptide-based drug discovery and the physicochemical properties of recently approved oral drugs. The section on drug class studies looks at antibody-drug conjugates and the discovery, evolution, and therapeutic potential of dopamine partial agonists. Featured case studies examine the discovery of Etelcalcetide for the treatment of secondary hyper-parathyroidism in patients with chronic kidney disease; the development of Lenvatinib Mesylate; the discovery and development of Venetoclax; and more.
-Focuses on recently introduced drugs that have not been featured in any textbooks or general references, including Ocrelizumab, a new generation of anti-CD-20 mAb for the treatment of multiple sclerosis, and Venetoclax, a selective antagonist of BCL-2
-Features personal experiences of successful drug developers from industry and academia
-Endorsed and supported by the International Union of Pure and Applied Chemistry (IUPAC)
Successful Drug Discovery: Volume 4 provides a fascinating and informative look into the process of drug discovery and would be a great reference for those in the pharmaceutical industry, organic and pharmaceutical chemists, and lecturers in pharmacy.
PART 1: General Aspects
Trends in Peptide-based Drug Discovery
Physicochemical Parameters of Recently Approved Oral Drugs
PART 2: Drug Class Studies
Antibody-Drug Conjugates: Empowering Antibodies for the Fight against Cancer
Dopamine Partial Agonists - Discovery, Evolution and Therapeutic Potential
PART 3: Case Studies
Discovery of Etelcalcetide for the Treatment of Secondary Hyperparathyroidism in Patients with Chronic Kidney Disease
Development of Lenvatinib Mesylate, an Angiogenesis Inhibitor Targeting VEGF and FGF Receptors
Ocrelizumab : A New Generation of anti-CD-20 mAb for the Treatment of Multiple Sclerosis
The Story of Rucaparib/Rubraca
Discovery and Development of Venetoclax, a Selective Antagonist of Bcl-2
Janos Fischer, PhD, is a Senior Research Scientist at Richter Plc., Budapest, Hungary, and is Chair of the Subcommittee on Drug Discovery and Development of IUPAC.
Christian Klein, PhD, is Head of Oncology Programs at the Roche Innovation Center Zurich, specialized in the discovery, validation and preclinical development of antibody based cancer immunotherapies and bispecific antibodies.
Wayne Childers, PhD, is Associate Professor of Pharmaceutical Sciences at Temple University, Philadelphia, USA.
- Edited by János Fischer
- Edited by Christian Klein
- Edited by Wayne E. Childers
Similar Books
Schloss – Gefängnis – Inferno
Historischer Abriss und ethische Aufarbeitung der NS-Krankenmorde in Erlangen
Abwendung sozialrechtlicher Vermögenssanktionen als Abrechnungsbetrug?
Zur Übertragbarkeit der Ausklammerung geldwerter staatlicher Sanktionen aus dem Vermögensbegriff auf den Vergütungsausschluss in der vertragsärztlichen Versorgung
Coaching und Beratung verboten?
Professionelle Unterstützung psychisch belasteter oder erkrankter Personen außerhalb der Heilkunde
Dal diritto della salute al diritto alla salute
Storia, istituzioni, problemi della sanità in Italia tra Otto e Novecento
Der Geist des Menschen und die originäre Erfahrung der Zerbrechlichkeit
Eine philosophisch-theologische Grundlegung nach Edith Stein im Dialog mit der medizinischen Anthropologie und der existentiellen Psychologie
Deutsche Vererbungsforschung vor und in der NS-Zeit
Individuelle Wege zwischen Biologie und Medizin: Günther Just (1892–1950), Heinrich Poll (1877–1939) und Fritz Steiniger (1908–1985)
Einwilligungsfähigkeit als Schlüssel zu Selbstbestimmung und Schutz in der medizinischen Behandlung
Eine rechtswissenschaftliche Untersuchung: Deutschland, Polen, Österreich
Elisabeth Schwarzhaupt
Lebensbericht der Juristin, Kämpferin für Gleichberechtigung und ersten Bundesministerin. Mit unveröffentlichten Quellen von Elisabeth Schwarzhaupt
Gesunde High Performance®
Mehr Erfolg, mehr Energie, mehr Zeit - mit Strategien aus Medizin, Neurowissenschaft, Sport und Wirtschaft
Potentiale Elementarer Musikpädagogik in ihrer Wirkung auf Grundschulkinder
Eine empirisch-quantitative Studie an österreichischen Volksschulen
Stark im Kopf
Gelassen bleiben, klar denken, gesund leben - Dein Kompass für mentale Stärke im Alltag
Systemisch gesund und resilient durch den Alltag
100 Impulskarten für Coaching, Beratung und Therapie