Natural Products Targeting Clinically Relevant Enzymes

Edited by Paula B. Andrade Edited by Patricia Valentao Edited by David M. Pereira

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Extent: 352 pages

Publisher: Wiley-VCH

Language: English

Hardback (Out of print)

(October 2017)

ISBN: 9783527342051

6.69 x 9.61 inches

Price: $199.00

On back order

The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more.

By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.

Natural products as enzyme inhibitors
Natural ACE inhibitors with antihypertensive properties
Hypoglycaemic effects of plants food constituents via inhibition of carbohydrate-hydrolysing enzymes: from chemistry to future applications.
Natural Product Inhibitors of Cyclooxygenase (COX) Enzymes: Current Status and Future Perspective
Natural Products Targeting Clinically Relevant Enzymes of Eicosanoid Biosynthesis implicated in inflammation and cancer
Natural inhibitors of mitochondrial respiratory chain: therapeutic and toxicological implications
Angiotensin-I-Converting enzyme (ACE-I) inhibitors from marine bio-resources
Refreshing the Marine-derived Chemotherapeutic Pipeline
Recent developments on the natural products and their derivatives targeting PfDHFR (Dihydrofolate reductase) and PfHSP (Heat sensitive protein)
Phospholipase A2 inhibitors of marine origin: a target for inflammation
Natural Plant-derived Acetylcholinesterase Inhibitors: Relevance for Alzheimer's disease
Molecular Targets of Clinically-Relevant Natural Products from Filamentous Marine Cyanobacteria
Natural inhibitors of beta-secretase
Anti-HIV natural products

  • Edited by Paula B. Andrade
  • Edited by Patricia Valentao
  • Edited by David M. Pereira