Chiral N,N’-Dioxide Amides in Asymmetric Catalysis

The success of the N,N’-dioxide amides and catalyst design not only represents a valuable addition to the toolkit of chiral ligand design but also enhances the stereo control of reactions with well-understood mechanisms. This enables unprecedented transformations to occur with high enantioselectivity. This book provides a complete narrative on the development, unique features, and efficiency of chiral N,N’-dioxide in a wide range of asymmetric transformations. It covers the historical development and evolution of chiral N,N’-dioxide amides, the application of chiral N,N’-dioxide amide organocatalysts in asymmetric synthesis, the detailed coordination chemistry and the structural aspects of N,N’-dioxide amides with various metals, and a comprehensive overview of their applications in different types of asymmetric reactions, including nucleophilic addition, oxidation/reduction, pericyclic reactions, and radical reactions. Moreover, it provides mechanistic insights into the catalytic processes facilitated by chiral N,N’-dioxide-metal complexes. This book is an invaluable reference for current methodologies and will inspire future innovations in chiral ligand design and application.

Chapter 01 Introduction
Chapter 02 The Application of N,N'-dioxides as Bifunctional Organocatalyst
Chapter 03 Polar Addition to Carbon-Hetero and Hetero-Hetero Double Bonds
Chapter 04 Conjugated Addition to Carbon-Carbon Unsaturated Bonds
Chapter 05 Friedel-Crafts Reaction
Chapter 06 Oxidation and Reduction Reactions
Chapter 07 Ring-Opening Reactions
Chapter 08 Pericyclic Reactions
Chapter 09 Rearrangement Reactions
Chapter 10 Cascade Reactions
Chapter 11 Combined Catalysis
Chapter 12 Radical Reactions and Photocatalysis
Chapter 13 Miscellaneous Reactions
Chapter 14 The Application of Other N-oxide and Phosphine Oxide in Asymmetric Catalysis

• Edited by Xiaoming Feng
• Edited by Xinghua Liu
• Edited by Shunxi Dong