Carbohydrate-based Drug Discovery

To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential.

Topics include the following:

> Chemical Synthesis of Carbohydrates

> Carbohydrate Biosynthesis and Metabolism

> Carbohydrate Analysis

> Cellular Functions of Carbohydrates

> Development of Carbohydrate-based Drugs

A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world’s leading carbohydrate chemists.

Complex Carbohydrate Synthesis
The Chemistry of Sialic Acid
Solid-Phase Oligosaccharide Synthesis
Solution and Polymer-supported Synthesis of Carbohydrates
Enzymatic Synthesis of Oligosaccharides
Glycopeptides and Glycoproteins: Synthetic Chemistry and Biology
Chemistry and Biochemistry of Asparagine-linked Protein Glycosylation
Conformational Analysis of C-Glycosides and Related Compounds
Synthetic Lipid A Analogs for Sepsis Treatment
Polysialic Acid Vaccines
Synthetic Carbohydrate-based Vaccines
Antithrombotics Based on Synthetic Oligosaccharides
Sequencing of Oligosaccharides and Glycoproteins
Analytical Techniques for the Characterization and Sequencing of Glycosaminoglycans
Synthetic Multivalent Carbohydrate Ligands as Effectors or Inhibitors of Biological Processes
Glycosyltransferase Inhibitors
RNA-Aminoglycoside Interactions
Glycosylated Natural Products
Small Molecule Inhibitors of the Sulfotransferases
Carbohydrate-based Treatment of Cancer Metastasis
N-Acetylneuraminic Acid Derivatives and Mimetics as Anti-influenza Agents
Carbohydrate-based Drug Discovery in the Battle Against Bacterial Infections
 
(partial contents)

• Edited by Chi-Huey Wong

"In summary, Carbohydrate-Based Drug Discovery Vols. 1 and 2 provide an appropriate and useful look at the current state of the art in this relevant and rapidly advancing field. I recommend the book to both experts and less expert readers."
 
Francesco Nicotra, Università di Milano-Bicocca (Italy)
ChemBioChem 4/2004
 
"To summarize, the work provides a comprehensive and excellent survey of the present situation in carbohydrate research, in which many interesting details can be spotted. Because of the wide range of topics covered, the reader will refer to it again and again. It is likely to become a standard work on the subject, not exclusively for carbohydrate chemistry enthusiasts."
 
Oliver Plettenburg, Ulrich Stilz
Angewandte Chemie + IE 2004-43/31
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"Leser mit soliden organisch-chemischen Kenntnissen werden ihre wahre Freude an diesem spannenden Einblick in die moderne Zuckerchemie haben."
 
BioTec März/April 2004
 
"Zusammenfassend stellt dieses Werk einerseits eine nahezu unerschöpfliche Quelle für den Chemiker und Forscher/Entwickler in der Pharmazeutischen Industrie dar. Andererseits zeigt es aber auch dem Mediziner, Pharmazeuten und Naturwissenschaftler neue, innovative Wege und Tendenzen...auf."
A. Schmidt
Der Mikrobiologe
 
"Insgesamt ist das vorliegende Werk eine umfassende und sehr gelungene Zusammenstellung des aktuellen Standes der Kohlenhydratforschung, in der es viel zu entdecken gibt. Der Facettenreichtum des diskutierten Stoffes wird den Leser immer wieder zu den beiden Bänden greifen lassen. Nicht nur für Freunde der Zuckerchemie sollte Carbohydrate-based Drug Discovery zu einem Standardwerk werden."
 
Oliver Plettenburg, Ulrich Stilz
Angewandte Chemie + IE 2004-43/31
 
"Professionalität und ein gutes wissenschaftliches Netzwerk zahlen sich für die Qualität eines derartig innovativen Werkes einer noch etwas stiefmütterlich behandelten Richtung der Wissenschaft nachhaltig aus."
 
A. Schmidt
Arzneimittel-Forschung / Drug Research 8/04
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