Biological Reaction Engineering

This book explains modeling and simulation of the dynamics of biological processes in a readily comprehensible manner, using the unique combination of simplified fundamental theory and direct hands-on computer simulation.



Biological systems modeled range from single enzymes to metabolic and multi-organism systems. The models for the kinetics are combined with the models of the reactors, which often include flow configuration and mass transfer aspects. In these many examples, bioreactor control and the optimization of their operation is also of interest. Simulation examples start from most simple ones reaching into recent research examples. The mathematics is kept to a minimum, and yet the numerous examples illustrate almost every aspect of biological engineering science, with each one described in detail, including the model equations.

 

The example programs are written in the modern, user-friendly simulation language Berkeley Madonna. Madonna solves models comprising many ordinary differential equations using very simple programming. Data may be included for curve fitting, and sensitivity or multiple runs may be performed. The results can be viewed simultaneously on multiple-graph windows or by using overlays. The examples can be varied to fit any real situation, and the suggested exercises provide practical guidance.

 

The extensive teaching and research experience of the authors is reflected in this well-balanced presentation, which is suitable for every biochemist, biologist, bioengineer and chemical engineer interested in modeling and simulation.

 

The applied software Berkeley Madonna for Mac and PC is available from the Berkeley Madonna website:

www.berkeleymadonna.com

 

By choosing Supplementary Material from this WILEY-VCH webpage, a Zip file can be downloaded. This contains all simulation example programs for the book, solutions of modeling exercises and a short description to using Berkeley Madonna.

 

Buyers of the book can buy the full Berkeley Madonna software at a reduced cost, as described in the appendix of the book.

 

Part I Principles of Bioreactor Modeling
Modeling Principles
Basic Bioreactor Concepts
Biological Kinetics
Bioreactor Modeling
Mass Transfer
Diffusion and Biological Reaction in Immobilized Biocatalyst Systems
Automatic Bioprocess Control Fundamental
Basic Cell and Bioreactor Models
Part II Dynamic Bioprocess Simulation Examples Using the BERKELEY MADONNA Simulation Language
Biological Reaction Process Modeling Examples
Simulation Examples of Biological Reaction Processes Using BERKELEY MADONNA
Appendix: Using the Berkeley Madonna Language and Accessing the Simulation Examples

• By (author) Elmar Heinzle
• By (author) Irving J. Dunn
• By (author) John Ingham
• By (author) Jiri E. Prenosil

"...ist das Buch eine echte Bereicherung und führt hoffentlich bei den Lesern zum angestrebten Schub an Interesse und Fähigkeit. Ich werde es jedenfalls in Griffweite neben dem Laptop postieren und den Studierenden in den einschlägigen Vorlesungen empfehlen."
 
C. Posten, Karlsruhe
CIT 3/04
 
"Besonders hervorzuheben ist der für ein Lehrbuch sehr erfreuliche durchgehend praktische Bezug. Das Buch ist meines Erachtens besonders gut für angehende Fachhochschulingenieure sowie für Studenten in Nebenfächern geeignet. Darüber hinaus kann es als erste Lektüre für denjenigen dienen, der sich in das Fachgebiet einarbeiten möchte."
 
Chemie Ingenieur Technik, B. Nienhaus, Frankfurt
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