Automated Carbohydrate Synthesis

Written by one of the leaders in the field of solid-phase carbohydrate synthesis, this practical book covers applications ranging from vaccines to cell signaling, synthetic peptides and asymmetric synthesis.

Readers will be able to speed up their carbohydrate synthesis using automation and select the right protocol to efficiently plan synthetic pathways. Furthermore, the accompanying CD contains the analytical data for carbohydrate structures for easy access.

A definite must-have for organic chemists and biochemists, whether in academia or industry.

Preface
 
Carbohydrates in Biology and Medicine
 
Chemical Synthesis of Carbohydrates
 
Automated Solid Phase Assembly of Oligosaccharides
 
Synthesis of Building Blocks
 
Synthesis of Resins and Linkers
 
Setup of the Automated Synthesizer
 
Cleavage of the Oligosaccharide from Resin and
 
Deprotection and Purification of the Final Product
Removal of the Protecting Groups
 
Analysis, Quality Control and Quantification of Synthetic Oligosaccharides
 
Case Studies
 
Placement of Linkers
 
Conclusion and Outlook

• By (author) Peter H. Seeberger
• By (author) Daniel B. Werz