Entwicklung einer biologisch adaptierten intensitatsmodulierten Strahlentherapieplanung auf der Basis molekularbiologischer Bildgebungsverfahren

by Mark Rickhey

Image coming soon

Extent: 120 pages

Publisher: Schnell & Steiner

Subjects: Medicine, Technical Sciences: Computer Science, Engineering, IT, & Math

Series: Dissertationsreihe / Physik

Series volume number: 4

Language: German

Paperback (Out of print)

(June 2009)

ISBN: 9783868450248

6.65 x 9.45 inches

Price: $33.00

Out of stock

Diese Arbeit behandelt die Entwicklung und Anwendung einer biologisch adaptierten Bestrahlungsplanung auf der Grundlage einer 18F-Fluoroethyltyrosin (18F-FET) Positronenemissionstomographie bei Hirntumoren. Im Gegensatz zur konventionellen Therapie fuhrt die Strahlentherapieplanung auf der Grundlage biologischer Bildgebung im Sinne von “Dosepainting by Numbers” zu einer heterogenen Dosisverschreibung innerhalb des Tumors. Als erster Ansatz wurde auf ein lineares Modell zuruckgegriffen um die Aktivitat eines Volumenelements auf die Dosisvorgabe abzubilden. Diese dreidimensionale Dosisverschreibung wurde in das inverse Monte Carlo Bestrahlungsplanungssystem IKO implementiert und es wurden Photonen- und Protonenbestrahlungsplane erstellt. Zusatzlich wurden die Moglichkeiten einer Dosiseskalation auf 18F-FET anreichernde Subvolumina innerhalb des Zielvolumens sowie einer Bestrahlungsplanung auf der Grundlage der Tumorkontrollwahrscheinlichkeit in weiteren Planungsstudien untersucht.

  • By (author) Mark Rickhey

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