Ectoparasites

This first book specifically dedicated to ectoparasite drug discovery is unique in providing insights from the veterinary as well as the medical perspective, covering research from both industry and academia while paving the way for new synergies between the two research communities.

Edited by a team combining 80 years of experience in academic research and industrial antiparasitic drug discovery, this volume of Drug Discovery in Infectious Diseases summarizes current knowledge in this rapidly expanding field. Comprehensive yet concise, this ready reference blends solid background information on ectoparasite biology with the very latest methods in ectoparasite drug discovery. Three major parts cover current ectoparasite control strategies and the threat of drug resistance, screening and drug evaluation, and the new isoxazoline class of ectoparasiticides. The future potential of mechanism-based approaches for repellents and parasiticides is thoroughly discussed, as are strategies for vaccines against ectoparasites, making the book ideal for parasitologists in academia as well as researchers working in the pharmaceutical industry.

PART ONE: Strategies & Resistance
Comparison of Anti-Ectoparasite and Anti-Endoparasite Therapies and Control Strategies
Vaccination Against Ticks
Blocking Transmission in Vector-borne Diseases
The Threat and Reality of Drug Resistance in Cattle Tick Rhipicephalus (Boophilus) microplus
Monitoring Drug Sensitivity in Cattle Ticks
New Developments in the Control of Human Lice
 
PART TWO: Screens & Models
Molecular Targets to Impair Blood Meal Processing in Ticks
Whole-organism Screens for Ectoparasites
In vitro Feeding Methods for Hematophagus Arthropods and Their Application in Drug Discovery
Testing in Laboratory Animal Models for Ectoparasiticide Discovery and Development
Testing in Target Hosts for Ectoparasiticide Discovery and Development
 
PART THREE: Isoxazolines
Isoxazolines: A Novel Chemotype Highly Effective on Ectoparasites
The Discovery of Afoxolaner: A New Ectoparasiticide for Dogs
Development of Afoxolaner as a New Ectoparasiticide for Dogs
Discovery, Development, and Commercialization of Sarolaner (Simparica®), A Novel Oral Isoxazoline Ectoparasiticide for Dogs
Isoxazolines: Preeminent Ectoparasiticides of the Early Twenty-first Century

• Edited by Charles Q. Meng
• Edited by Ann E. Sluder
• Series edited by Paul M. Selzer