Iron-Sulfur Clusters

An authoritative and up-to-date collection of resources covering the ubiquitous iron-sulfur cluster-containing proteins

 

In Iron-Sulfur Clusters: Biogenesis and Biochemistry, a team of distinguished researchers delivers an incisive and practical discussion of the assembly and role of metalloproteins containing an iron atom in a mononuclear or binuclear metal-active site, or where the assembly and final activity of the enzyme depends on an Fe-S cluster containing protein.

 

The book examines the crosstalk in the assembly of metal-active sites and the roles played by various metal ions in polynuclear metalloclusters. It also describes metal homeostasis and trafficking in a cellular context and explains why the availability of metal ions is tightly regulated.

 

Of particular interest to chemists working with iron-sulfur (Fe-S) clusters in biology, biochemistry, pharmaceuticals, and drug synthesis, the book also contains:

 

* A thorough introduction to the biosynthesis of hydrogenase cofactors and hydrogenase reaction mechanisms

* Comprehensive explorations of the reaction mechanisms of molybdoenzymes, including sulfite oxidase, aldehyde oxidase, and formate dehydrogenase

* Practical discussions of the biosynthesis of Fe-S clusters in prokaryotes and eukaryotes

* Complete examinations of the insertion of Fe-S clusters and the biosynthesis of Moco and FeMoco

* An overview of the chemical, crystallographic, spectroscopic and theoretical methods commonly used to characterize Fe-S clusters.

 

Perfect for biochemists and protein, pharmaceutical, bioinorganic, and organic chemists, Iron-Sulfur Clusters will also be useful for food and environmental chemists, as well as professionals working in the pharmaceutical industry.

Volume I
1.ISC-based Fe-S cluster assembly and insertion in prokaryotes
2.SUF-based Fe-S cluster assembly in prokaryotes
3.Mitochondrial Fe-S cluster assembly in eukaryotes
4.Cytosolic Fe-S cluster assembly in eukaryotes
5.Aldehyde oxidase
6.Sulfur acquisition in methanogens
7.Moco Biosynthesis in bacteria
8.Moco Biosynthesis in eukaryotes
9.Biosynthesis of Fe-S clusters by NifS/U
10.Alternative substrates of nitrogenases
 
Volume II
1.Bifurcating hydrogenases
2.Biosynthesis of [FeFe]-hydrogenase
3.Biosynthesis of [NiFe]-hydrogenase
4.Biosynthesis of [Fe]-hydrogenase
5.Hydrogenase reaction mechanism
6.Introduction into X-ray Chrystallography
7.Vibrational Spectroscopy
8.Theoretical studies
9.Model compounds and inorganic chemistry
10.Formate dehydrogenases

• Edited by Silke Leimkühler
• Edited by Günter Schwarz
• Edited by Oliver Lenz
• Edited by Oliver Einsle