Fundamental Bioengineering

A thorough introduction to the basics of bioengineering, with a focus on applications in the emerging “white” biotechnology industry. As such, this latest volume in the “Advanced Biotechnology” series covers the principles for the design and analysis of industrial bioprocesses as well as the design of bioremediation systems, and several biomedical applications. No fewer than seven chapters introduce stoichiometry, kinetics, thermodynamics and the design of ideal and real bioreactors, illustrated by more than 50 practical examples. Further chapters deal with the tools that enable an understanding of the behavior of cell cultures and enzymatically catalyzed reactions, while others discuss the analysis of cultures at the level of the cell, as well as structural frameworks for the successful scale-up of bioreactions. In addition, a short survey of downstream processing options and the control of bioreactions is given.

1. Introduction
 
Part I - Bioreaction Engineering
 
2. Experimentally Determined Rates of Bio-reactions
3. Redox Balances and Consistency Check of Experiments
4. Primary Metabolic Pathways and Metabolic Flux Analysis
5. A Primer to 13C Metabolic Flux Analysis
6. Genome Scale Models
7. Kinetics of Bio-reactions
8. Application of Dynamic Network Models for Optimal Redesign of Cell Factories
9. Chemical Thermodynamics Applied in Bioengineering
 
Part II - Bioreactors
 
10. Design of Ideal Bioreactors
11. Mixing and Mass Transfer in Industrial Bioreactors
 
Part III - Downstream Processing
 
12. Product Recovery from the Cultures
13. Purification of Bio-products
 
Part IV - Process Development, Management and Control
 
14. Real Time Measurement and Monitoring of Bioprocesses
15. Control of Bio-processes
16. Scale-up and Scale down
17. Commercial Development of Fermentation Processes

• Edited by John Villadsen
• Series edited by Sang Yup Lee
• Series edited by Jens Nielsen
• Series edited by Gregory Stephanopoulos